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DISCUSSIONMelasma is a painful chronic disease that therapy often present a challenge. 4-n-Butylresorcinol is a newly developed Hypopigmenting which has an inhibitory effect against tyrosinase and TRP-1. The effectiveness of the Hypopigmenting of 4-n-Butylresorcinol showed many such in vitro and in vivo studies reported in 19953-10. In a 18 trial, 4-n-Butylresorcinol-0 placebo-controlled clinical weeks. 3% of induced a significant improvement in serum in patients with pigmentation post laser, compared to placebo group8. For patients of melasma, 4-n-Butylresorcinol 0. 3% serum is found, be effective in a study9 open 24 week treatment in 84% of patients with Chloasma. In another recent control randomized, double-blind, vehicle, split-face study of 28 patients with Chloasma, 4-n-Butylresorcinol 0. 3% serum has been found to have a colorimetric efficiency much more as a control of the vehicle after the 12 weeks, based on clinical evaluations and measurements10. However, a relatively long duration of use 4-n-Butylresorcinol was needed to achieve the effect of Hypopigmenting in previous studies. In addition, the revitol scar removal cream south africa side effects, including mild Erythema, dryness, peeling and flaking, 8/28 patients (6%) in 28 tests were a last double Studie10. As a result, we have developed this clinical study with a lower concentration of 4-n-Butylresorcinol. To the best of our knowledge, this is the first study that has evaluated the effects of the n-Butylresorcinol 4-0. 1% of patients with Melasma cream. With respect to the vehicle, 4-n-0 Butylresorcinol 1% cream has shown significant efficacy even after 4 weeks of treatment, which lasted until the end of the study. In general, were the average change in the MI at the end of the study for skin 4-n - treated Butylresorcinol and the skin of the vehicle 4. 87% and + 2. 21% or with a statistically significant (p) difference,.